Here are the best of the best:
Peanuts by Charles M. Schultz is the ultimate classic. People have enjoyed the antics of Snoopy, Charlie Brown, Lucy, Linus, and the rest of the gang for decades. Chuck Schultz continued to draw his daily strips until his very last days. Even in those final years, when readers could see the squiggled lines produced by his shaking hands, the comic was as hilarious and insightful as ever. Mr. Schultz is missed, but the memory of the wonderful characters he created will live on forever.
Bloom County by Berkely Breathed is probably my favorite comic strip of all time. Every single character, from Opus to Steve Dallas to Bill the Cat, were memorable and laugh-inducing. Mr. Breathed is finally coming out with a five-volume collection of all his Bloom County strips in chronological order called Bloom County: The Complete History, and fans of his work couldn't be happier.
Calvin and Hobbes by Bill Watterson was, at many times, an unrivaled work of art. The story of the mischievous little boy with an out-of-control imagination and his pet stuffed tiger will live on as a masterpiece.
The Farside by Gary Larson continues to be probably one of the most posted comic strips on people's bulletin boards, offices, and refrigerators. How one man could come up with such outrageously funny scenarios is beyond my comprehension. Maybe that's why he eventually stopped creating the one-panel comic, because who continue such a streak of non-stop hilarity?