As you can see, I didn't include some of the more recent flops, such as John Carter, Jack Reacher, Green Lantern, I Am Number Four, and others, because even though I cannot see how anyone could justify following up those duds, it's still too early to tell if the studios will roll the dice again. Sometimes a disappointing first film does not mean the death of a possible film franchise -- just look at Star Trek: The Motion Picture as a perfect example.
There are so many others. Have I left any of your favorites off the list? Let me know.